Search on: SQUALENE MONOOXYGENASE 
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Descriptor English:   Squalene Monooxygenase 
Descriptor Spanish:   Escualeno-Monooxigenasa 
Descriptor Portuguese:   Esqualeno Mono-Oxigenase 
Synonyms English:   Squalene Epoxidase
Squalene Monooxygenase (2,3-Epoxidizing)
Epoxidase, Squalene
Monooxygenase, Squalene  
Tree Number:   D08.811.682.690.708.749
Definition English:   The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide. 
History Note English:   2006(1980); use ETHERS, CYCLIC 1970-1979 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50664 
Unique Identifier:   D050603 

Occurrence in VHL:
 

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